Mucosal transmissibility disease induction and coreceptor switching of R5 SHIVSF162P3N molecular clones in rhesus macaques

摘要

BackgroundMucosally transmissible and pathogenic CCR5 (R5)-tropic simian-human immunodeficiency virus (SHIV) molecular clones are useful reagents to identity neutralization escape in HIV-1 vaccine experiments and to study the envelope evolutionary process and mechanistic basis for coreceptor switch during the course of natural infection.