The adverse effects or overdose of thioridazine including sudden death, fatal arrhythmia, or retinopathy, in addition to the neurological signs have been reported. A three-year-old boy with bronchitis was prescribed erythromycin by a local clinic, but he started to complain of severe drowsiness and became unconscious. It was decided that this was a result of a compounding error of thioridazine instead of erythromycin owing to their similar commercial names. The thioridazine concentration in the child's serum on admission was two to three times higher than the Cmax for adults with the same dosage. The concentration of the lavage saline on admission was only 0.3% of the ingested amount, indicating that the lavage was not effective in our case. Pharmacokinetic analysis revealed the parameters as Tmax, 1.5 hr; Cmax, 1700 ng/mL; Ka, 2.01 L/hr; Vd, 3.6 L/kg; and T1/2, 6.8 hr. Further investigations on clinical cases with a pharmacokinetic analysis should be done to confirm the pharmacokinetic evidence obtained here and to give specific therapeutic guidelines for overdose management especially in children.
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机译：据报道，除了神经系统症状外，还有硫代达达嗪的不良反应或服用过量，包括猝死，致命性心律失常或视网膜病变。当地诊所向一名三岁的支气管炎男孩开出了红霉素的处方，但他开始抱怨严重嗜睡并失去知觉。可以确定这是由于硫代哒嗪而不是红霉素的混合错误，因为它们的商业名称相似。相同剂量的成人入院时儿童血清中的硫代哒嗪浓度比Cmax高2至3倍。入院时灌洗盐水的浓度仅为摄入量的0.3％，表明在本例中灌洗无效。药代动力学分析显示参数为Tmax，1.5小时； Cmax，1700 ng / mL；钾，2.01 L / hr; Vd，3.6 L / kg；和T1 / 2，6.8小时。应使用药代动力学分析对临床病例进行进一步研究，以确认此处获得的药代动力学证据，并为过量用药（尤其是儿童）的过量使用提供具体的治疗指南。
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