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Intranasal Pharmacokinetics of Morphine ARER a Novel Abuse-Deterrent Formulation: Results from a Randomized Double-Blind Four-Way Crossover Study in Nondependent Opioid-Experienced Subjects

机译：吗啡ARER的鼻内药代动力学一种新型的抑制滥用制剂：来自非依赖类阿片类药物的受试者的随机双盲四向交叉研究结果

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摘要

Objective To investigate the pharmacokinetics (PK) of Morphine ARER, an extended-release (ER), abuse-deterrent formulation of morphine sulfate after oral and intranasal administration.

机译：目的研究吗啡ARER的药代动力学（PK），它是口服和鼻内给药后的吗啡硫酸盐吗啡的缓释（ER）滥用抑制剂。

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期刊名称 Pain Research Management
作者
Lynn R. Webster; Carmela Pantaleon; Matthew Iverson; Michael D. Smith; Eric R. Kinzler; Stefan Aigner;
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年(卷),期 2018(2018),-1
年度 2018
页码 7276021
总页数 10
原文格式 PDF
正文语种
中图分类神经病学;
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专利

1. Intranasal Pharmacokinetics of Morphine ARER, a Novel Abuse-Deterrent Formulation: Results from a Randomized, Double-Blind, Four-Way Crossover Study in Nondependent, Opioid-Experienced Subjects [J] . Lynn R. Webster, Carmela Pantaleon, Matthew Iverson, Pain research & management: the journal of the Canadian Pain Society = journal de la socie?te? canadienne pour le traitement de la douleur . 2018,第10期

机译：吗啡ARER的鼻内药代动力学，一种新型的抑制滥用制剂：来自非依赖类阿片类药物的受试者的一项随机，双盲，四向交叉研究的结果
2. Intranasal Pharmacokinetics of Morphine ARER, a Novel Abuse-Deterrent Formulation: Results from a Randomized, Double-Blind, Four-Way Crossover Study in Nondependent, Opioid-Experienced Subjects [J] . Lynn R. Webster, Carmela Pantaleon, Matthew Iverson, Pain research & management: the journal of the Canadian Pain Society = journal de la socie?te? canadienne pour le traitement de la douleur . 2018,第Pta1期

机译：吗啡·arer的鼻内药代动力学，一种新型滥用威慑制剂：由无依赖，阿片类药物经验丰富的受试者的随机，双盲，四通交叉研究的结果
3. A Randomized, Double-Blind, Double-Dummy, Placebo-Controlled, Intranasal Drug Liking Study on a Novel Abuse-Deterrent Formulation of Morphine-Morphine ARER [J] . Webster Lynn R., Pantaleon Carmela, Shah Manish S., Pain medicine : . 2017,第7期

机译：一种随机，双盲，双伪，安慰剂对照滥用滥用性制剂的鼻内药物喜欢研究吗啡 - 吗啡arer
4. A Phase I, Double-Blind, Randomized, Dose Escalating Crossover Study ofan Oral Formulation of Human Growth Hormone in Healthy Male Volunteers [C] . Steven M. Dinh, Puchun Liu, Ehud Arbit, Controlled Release Society annual meeting . 2004

机译：健康男性志愿者中人类生长激素口服制剂的I期，双盲，随机，剂量递增交叉研究
5. A Randomized, Double-Blind, Placebo-Controlled Crossover Trial Evaluating the Effect of Intranasal Insulin on Cognition and Emotional Processing in Individuals with Treatment-Resistant Major Depressive Disorder. [D] . Cha, Danielle Soh-Young. 2016

机译：一项随机，双盲，安慰剂对照的交叉试验评估了鼻内胰岛素对难治性重度抑郁症患者认知和情绪加工的影响。
6. A Randomized Double-Blind Double-Dummy Study to Evaluate the Intranasal Human Abuse Potential and Pharmacokinetics of a Novel Extended-Release Abuse-Deterrent Formulation of Oxycodone [O] . Lynn R. Webster, Ernest A. Kopecky, Michael D. Smith, -1

机译：一项随机双盲双虚拟研究评估羟考酮新型延长释放滥用抑制制剂的鼻内人类滥用潜力和药代动力学
7. Intranasal Pharmacokinetics of Morphine ARER, a Novel Abuse-Deterrent Formulation: Results from a Randomized, Double-Blind, Four-Way Crossover Study in Nondependent, Opioid-Experienced Subjects [O] . Lynn R. Webster, Carmela Pantaleon, Matthew Iverson, 2018

机译：吗啡·arer的鼻内药代动力学，一种新的滥用威慑制剂：由非依赖性，阿片类药物经验丰富的受试者进行随机，双盲，四通交叉研究的结果

Intranasal Pharmacokinetics of Morphine ARER a Novel Abuse-Deterrent Formulation: Results from a Randomized Double-Blind Four-Way Crossover Study in Nondependent Opioid-Experienced Subjects

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