Efficacy of Prophylactic Treatment for Oxycodone‐Induced Nausea and Vomiting Among Patients with Cancer Pain (POINT): A Randomized Placebo‐Controlled Double‐Blind Trial

摘要

Background.Although opioid‐induced nausea and vomiting (OINV) often result in analgesic undertreatment in patients with cancer, no randomized controlled trials have evaluated the efficacy of prophylactic antiemetics for preventing OINV. We conducted this randomized, placebo‐controlled, double‐blind trial to evaluate the efficacy and safety of prophylactic treatment with prochlorperazine for preventing OINV.