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Single-Agent Panitumumab in Frail Elderly Patients With Advanced RAS and BRAF Wild-Type Colorectal Cancer: Challenging Drug Label to Light Up New Hope

机译：晚期RAS和BRAF野生型结直肠癌的年老体弱患者中的单剂帕尼单抗：具有挑战性的药物标签点亮新希望

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Background.No prospective trials have specifically addressed the efficacy and safety of panitumumab in elderly patients with metastatic colorectal cancer (CRC). We aimed at assessing the efficacy and safety of single agent panitumumab in “frail” elderly patients diagnosed with metastatic RAS and BRAF wild-type CRC.

机译：背景：尚无前瞻性试验专门针对帕尼单抗对老年转移性结直肠癌（CRC）患者的疗效和安全性的研究。我们旨在评估单药帕尼单抗在诊断为转移性RAS和BRAF野生型CRC的“脆弱”老年患者中的疗效和安全性。

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期刊名称 The Oncologist
作者
Filippo Pietrantonio; Chiara Cremolini; Giuseppe Aprile; Sara Lonardi; Armando Orlandi; Alessia Mennitto; Rosa Berenato; Carlotta Antoniotti; Mariaelena Casagrande; Valentina Marsico; Federica Marmorino; Giovanni Gerardo Cardellino; Francesca Bergamo; Gianluca Tomasello; Vincenzo Formica; Raffaella Longarini; Elisa Giommoni; Marta Caporale; Maria Di Bartolomeo; Fotios Loupakis; Filippo de Braud;
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年(卷),期 2015(20),11
年度 2015
页码 1261–1265
总页数 5
原文格式 PDF
正文语种
中图分类肿瘤学;
关键词
Elderly Frail Metastatic colorectal cancer Panitumumab;

机译：老年人;体弱;转移性大肠癌;帕尼单抗;

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1. Single-Agent Panitumumab in Frail Elderly Patients With Advanced RAS and BRAF Wild-Type Colorectal Cancer: Challenging Drug Label to Light Up New Hope [J] . Pietrantonio Filippo, Cremolini Chiara, Aprile Giuseppe, The oncologist . 2015,第11期

机译：晚期RAS和BRAF野生型结直肠癌的年老体弱患者中的单剂帕尼单抗：具有挑战性的药物标签点亮了新希望
2. Single-Agent Panitumumab in Frail Elderly Patients With Advanced RAS and BRAF Wild-Type Colorectal Cancer: Challenging Drug Label to Light Up New Hope [J] . Filippo Pietrantonio, Chiara Cremolini, Giuseppe Aprile, The oncologist . 2015,第11期

机译：晚期RAS和BRAF野生型结直肠癌的年老体弱患者单药帕尼单抗：具有挑战性的药物标签点亮新希望
3. First-line single-agent panitumumab in frail elderly patients with wild-type KRAS metastatic colorectal cancer and poor prognostic factors: A phase II study of the Spanish Cooperative Group for the Treatment of Digestive Tumours [J] . Sastre J., Massuti B., Pulido G., European journal of cancer: official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR) . 2015,第11期

机译：一线单药panitumumab用于年老的野生型KRAS转移性结直肠癌和不良预后因素的老年患者：西班牙合作小组治疗消化道肿瘤的II期研究
4. Isolation of Circulating Tumor Cells from Patients with Metastatic Colorectal Cancer Using Label-Free Microfluidic Technology for Enumeration and Detection of KRAS, BRAF, PIK3CA Mutation [C] . Haiyan Emily Liu, Evelyn Kidess-Sigal, Melanie Triboulet, International Molecular Medicine Tri-Conference. . 2016

机译：使用无标记微流体技术分离转移性结肠直肠癌患者的循环肿瘤细胞进行募准和检测KRA，BRAF，PIK3CA突变
5. Glucose deprivation selects for KRAS and BRAF mutations in colorectal cancer. [D] . Yun, Jihye. 2009

机译：葡萄糖剥夺选择结直肠癌中的KRAS和BRAF突变。
6. First-line single-agent panitumumab in frail elderly patients with wild-type RAS unresectable colorectal cancer: a phase II study protocol OGSG 1602 [O] . Tetsuji Terazawa, Takeshi Kato, Masahiro Goto, 2019

机译：一线单药panitumumab用于年老的野生型RAS无法切除的结直肠癌患者：II期研究方案OGSG 1602
7. Single-agent panitumumab in frail elderly patients with advanced RAS and BRAF wild-type colorectal cancer: Challenging drug label to light up new hope [O] . Pietrantonio, Filippo, Cremolini, Chiara, Aprile, Giuseppe, 2015

机译：晚期RAS和BRAF野生型结直肠癌的年老体弱患者单药帕尼单抗：具有挑战性的药物标签点亮新希望

Single-Agent Panitumumab in Frail Elderly Patients With Advanced RAS and BRAF Wild-Type Colorectal Cancer: Challenging Drug Label to Light Up New Hope

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