Brain activation underlying turning in Parkinson’s disease patients with and without freezing of gait: a virtual reality fMRI study

摘要

Background:Freezing of gait is a debilitating symptom affecting many patients with Parkinson’s disease (PD), causing severe immobility and decreased quality of life. Turning is known to be the most common trigger for freezing and also causes the highest rates of falls. However, the pathophysiological basis for these effects is not well understood.