首页> 美国卫生研究院文献>Neuro-Oncology >NSRG-05. SAFETY OF ULTRASOUND-INDUCED BLOOD-BRAIN BARRIER OPENING IN PEDIATRIC PATIENTS WITH REFRACTORY SUS-TENTORIAL MALIGNANT BRAIN TUMORS BEFORE CHEMOTHERAPY ADMINISTRATION – THE SONOKID CLINICAL TRIAL

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NSRG-05. SAFETY OF ULTRASOUND-INDUCED BLOOD-BRAIN BARRIER OPENING IN PEDIATRIC PATIENTS WITH REFRACTORY SUS-TENTORIAL MALIGNANT BRAIN TUMORS BEFORE CHEMOTHERAPY ADMINISTRATION – THE SONOKID CLINICAL TRIAL

机译：NSRG-05。在进行化学治疗之前超声诱导的顽固性SUS-TEN恶性脑瘤的小儿患者的血脑屏障开放安全性-SONOKID临床试验

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OBJECTIVETo determine the safety of repeated disruption of the blood-brain barrier (BBB) by low intensity pulsed ultrasound (LIPU) with the Sonocloud^® device in children with recurrent malignant supra-tentorial brain tumors prior to intra-venous carboplatin chemotherapy. The safety of this procedure is currently being validated in adult patients with recurrent glioblastoma (Carpentier et al. 2016). MATERIAL AND

机译：目的确定使用Snocloud ^{®装置通过低强度脉冲超声（LIPU）反复破坏血脑屏障（BBB）对复发性恶性上颌前脑肿瘤复发儿童的安全性。静脉卡铂化疗。该方法的安全性目前已在成年复发性胶质母细胞瘤患者中得到验证（Carpentier等，2016）。材料和}

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期刊名称 Neuro-Oncology
作者
K Beccaria; M Canney; G Bouchoux; S Zohar; N Boddaert; F Bourdeaut; F Doz; C Dufour; J Grill; A Carpentier; S Puget;
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年(卷),期 2018(20),Suppl 2
年度 2018
页码 i146
总页数 1
原文格式 PDF
正文语种
中图分类神经病学;肿瘤学;
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专利

1. R-CHOP Preceded By Engineered Tumor Necrosis Factor (TNF) in Patients with Relapsed or Refractory (r/r) Primary CNS Lymphoma (PCNSL): Results of Antitumor Activity, Safety and Blood-Brain Barrier (BBB) Permeabilization in the "Ingrid" Phase II Trial [J] . Ferreri Andres J. M., Calimeri Teresa, Conte Gian Marco, Blood: The Journal of the American Society of Hematology . 2018,第NovaelaTreatmentAppr期

机译：在复发或难治性（R / R）原发性CNS淋巴瘤（PCNSL）的患者中之前由工程肿瘤坏死因子（TNF）之前的R-Checs：抗肿瘤活性，安全性和血脑屏障（BBB）渗透在“Ingrid”中的结果。第二阶段试验
2. Delivery of chemotherapy and antibodies across the blood-brain barrier and the role of chemoprotection, in primary and metastatic brain tumors: report of the Eleventh Annual Blood-Brain Barrier Consortium meeting. [J] . Doolittle ND, Peereboom DM, Christoforidis GA, Journal of neuro-oncology. . 2007,第1期

机译：在原发性和转移性脑肿瘤中跨血脑屏障提供化学疗法和抗体，以及化学保护的作用：第十一届年度血脑屏障联盟会议的报告。
3. Overcoming the blood-brain barrier in chemotherapy treatment of pediatric brain tumors. [J] . Linfeng Wu, Xiaoxun Li, Dileep R Janagam, Pharmaceutical research . 2014,第3期

机译：在小儿脑肿瘤的化学疗法中克服血脑屏障。
4. Evaluation of anticancer agent transport in brain tumors after focused ultrasound-induced blood-brain/blood-tumor barrier disruption [C] . Costas Arvanitis, Vasileios Askoxylakis, Yutong Guo, IEEE International Ultrasonics Symposium . 2017

机译：超声聚焦诱导的血脑/血肿瘤屏障破坏后脑肿瘤中抗癌剂转运的评估
5. Pharmacodynamic Analysis of Magnetic Resonance Imaging-Monitored Focused Ultrasound-Induced Blood-Brain Barrier Opening for Drug Delivery to Brain Tumors [O] . Po-Chun Chu, Wen-Yen Chai, Han-Yi Hsieh, 2006

机译：磁共振成像监测的聚焦超声诱导的血脑屏障开放的药物动力学分析，用于向脑肿瘤的药物递送。
6. Enhanced chemotherapy delivery by intraarterial infusion and blood-brain barrier disruption in malignant brain tumors [O] . David Fortin, Annick Desjardins, Andrew Benko, 2005

机译：通过神经内输注和恶性脑肿瘤的血脑屏障破坏增强化疗递送

NSRG-05. SAFETY OF ULTRASOUND-INDUCED BLOOD-BRAIN BARRIER OPENING IN PEDIATRIC PATIENTS WITH REFRACTORY SUS-TENTORIAL MALIGNANT BRAIN TUMORS BEFORE CHEMOTHERAPY ADMINISTRATION – THE SONOKID CLINICAL TRIAL

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