SCDT-37. MODULATION OF CONVECTION ENHANCED DELIVERY (CED) DISTRIBUTION USING FOCUSED ULTRASOUND (FUS)

摘要

INTRODUCTIONIneffective drug delivery across the blood brain barrier (BBB) is one purported factor that contributes to the lack of therapeutic benefit of systemic chemotherapy for brain tumors. Convection enhanced delivery (CED) is an appealing form of therapeutic drug delivery to the brain that bypasses the BBB while avoiding systemic toxicity. When considering highly diffuse and infiltrative tumors, adequate tumor coverage might not always be possible. Catheter design, infusion parameters, and multi-centric targeting have all been explored as means to alter distribution following CED. The ability to actively modulate infusion volume would be an appealing feature of a CED-based platform. We hypothesize that magnetic resonance-guided focused ultrasound (MRgFUS) may provide a means for modulating CED distribution.