SCDT-08. INJECTABLE DIBLOCK COPOLYPEPTIDE HYDROGEL PROVIDES A PROLONGED LOCAL DEPOT OF PACLITAXEL THAT PROVIDES LOCAL TUMOR CONTROL IN A PATIENT-DERIVED XENOTRANSPLANT MODEL OF GLIOBLASTOMA

摘要

INTRODUCTIONThe treatment of glioblastoma is limited by the fact that most oral/IV chemotherapy regimens are not able to cross the blood-brain barrier. While previous studies have designed modalities to directly deliver chemotherapeutic compounds in situ, few if any of these studies directly tested these modalities in a realistic in vivo system. In this study we investigate a minimally invasive carrier system that delivers potent amounts of any chemotherapeutic compound in an intracranial xeno-transplant model using patient-derived glioblastoma cells.