NCOG-07. MEMORY FUNCTIONING IN LOW-GRADE GLIOMA PATIENTS TREATED WITH EITHER RADIOTHERAPY (RT) OR TEMOZOLOMIDE (TMZ) CHEMOTHERAPY. A CORRELATIVE ANALYSIS OF EUROPEAN ORGANIZATION FOR RESEARCH AND TREATMENT (EORTC) STUDY 22033-26033

摘要

BACKGROUNDIn EORTC study 22033−26033 primary treatment with radiotherapy was compared to temozolomide chemotherapy alone in patients with high-risk low-grade glioma. There was no difference in progression-free survival between treatment modalities [Baumert et al. Lancet Oncol. 2016;17:1521-1532]. Considering the potential long-term deleterious impact of radiotherapy on memory functioning, this study also focused on the question whether temozolomide chemotherapy would be associated with a more favorable neurotoxic profile regarding memory functioning.