ACTR-82. LASER INTERSTITIAL THERMAL THERAPY (LITT) OF RECURRENT GLIOBLASTOMA (GBM) INDUCES TEMPORARY DISRUPTION OF THE PERITUMORAL BLOOD BRAIN BARRIER (BBB) AND MAY IMPROVE EFFICACY OF CHEMOTHERAPY WITH POOR CNS PENETRATION

摘要

BACKGROUNDInadequate drug delivery across the BBB is a major limiting factor in brain cancer therapy. Since most GBM recurrences occur within the peritumoral region where infiltrating glioma cells reside, peritumoral BBB disruption may help improve drug delivery and efficacy. LITT, a minimally invasive cytoreductive treatment for brain tumors, may disrupt the peritumoral BBB as evidenced by post-ablation contrast enhancement.