RT-33OUTCOME OF GLIOBLASTOMA IN THE POST-STUPP ERA: A SINGLE CENTRE RETROSPECTIVE AUDIT

摘要

BACKGROUND: Glioblastoma is the most common primary brain tumour in adults. Prior to the introduction of the Stupp protocol an audit by the Northern Centre for Cancer Care (NCCC) found a mean survival time of 12.4 months [1] using the standard regime at the time of radiotherapy alone (comparing favorably to Stupp control group under the same regime). However in 2005, Stupp et. al demonstrated an increase in mean survival time in their data from 12.1 months to 14.6 months with a new regime of radical radiotherapy with concurrent and adjuvant chemotherapy using temozolomide [2]. In 2009/2010 this protocol was implemented locally. AIMS: Assess whether expected life expectancy is being achieved as per the Stupp chemoradiotherapy regime standard [2]. METHODS: Retrospective study with data from electronic notes of 105 consecutive patients over 18 years of age who began radical therapy for glioblastoma (Grade 4) between December 2009 – December 2013. Mean survival calculated from surgery date of patients. Age range of the patients was 19-70 years with a median age of 54.85 years. RESULTS: Mean survival time 19 months (±2.3) (range: 4-44+ months). 6, 12, 18 and 24 month survival times were 92.8%, 71.9%, 50.4% and 35.8% respectively. CONCLUSIONS: Mean survival time and 6, 12, 18 and 24 month percentage survival exceeds Stupp data and previous departmental audit, demonstrating the success of the unit.