Effects of Ramiprilat-Coated Stents on Neointimal Hyperplasia Inflammation and Arterial Healing in a Porcine Coronary Restenosis Model

摘要

Background and ObjectivesThe renin-angiotensin-aldosterone system has been implicated in the pathogenesis of neointimal hyperplasia, and a role for angiotensin II in the migration and proliferation of vascular smooth muscle cells in restenotic lesions has been proposed. The aim of this study was to determine the anti-proliferative and anti-inflammatory effects of ramiprilat-coated stents in a porcine coronary overstretch restenosis model.