Guignardones P–S New Meroterpenoids from the Endophytic Fungus Guignardia mangiferae A348 Derived from the Medicinal Plant Smilax glabra

摘要

Four new meroterpenoids, guignardones P–S (>1–>4), and three known analogues (>5–>7) were isolated from the endophytic fungal strain Guignardia mangiferae A348. Their structures were elucidated on the basis of spectroscopic analysis and single crystal X-ray diffraction. All the isolated compounds were evaluated for their inhibitory effects on SF-268, MCF-7, and NCI-H460 human cancer cell lines. Compounds >2 and >4 exhibited weak inhibitions of cell proliferation against MCF-7 cell line.