α-Glucosidase Inhibitory Constituents from Acanthopanax senticosus Harm Leaves

摘要

A new triterpene glycoside, 3-O-[(α-L-rhamnopyranosyl)(1→2)]-[β-D-glucuronopyranosyl-6-O-methyl ester]-olean-12-ene-28-olic acid (>1) and a new indole alkaloid, 5-methoxy-2-oxoindolin-3-acetic acid methyl ester (>5) were isolated from the leaves of Acanthopanax senticosus Harms along with six known compounds. The structures of the new compounds were determined by means of 2D-NMR experiments and chemical methods. All the isolated compounds were evaluated for their glycosidase inhibition activities and compound >6 showed significant α-glucosidase inhibition activity.