An Improved Three Step Synthesis of (-)-3β-Hydroxycarvone from (-)-Carvone

摘要

(-)-Carvone (>3) has been efficiently transformed into (-)-3β-hydroxycarvone (>1), which is expected to be a useful synthon or chiral template in the synthesis of natural molecules. This short and efficient synthesis of compound >1 involves regioselective and stereoselective α-hydroxylation of carvone via the trimethylsilyl-dienyl-ether derivative.