Tumor necrosis factor-alpha (− 308G/A + 488G/A − 857C/T and -1031 T/C) gene polymorphisms and risk of ischemic stroke in north Indian population: A hospital based case–control study

摘要

BackgroundGenetic factors may play a role in the susceptibility of Ischemic stroke (IS). Previous studies have shown that Tumour necrosis factor-α (TNF-α) gene polymorphisms were associated with the risk of IS in multiple ethnicities. The present case–control study tested the hypothesis that genetic polymorphisms of the TNF-α gene may affect the risk of IS in North Indian population. We investigated the association of four single nucleotide polymorphisms (− 308G/A, + 488G/A, − 857C/T and -1031 T/C) within TNF-α gene promoter and their haplotypes with the risk of IS.