Overexpression of Biglycan is Associated with Resistance to Rapamycin in Human WERI-Rb-1 Retinoblastoma Cells by Inducing the Activation of the Phosphatidylinositol 3-Kinases (PI3K)/Akt/Nuclear Factor kappa B (NF-κB) Signaling Pathway

机译：Biglycan的过表达与人类WERI-Rb-1视网膜母细胞瘤细胞中对雷帕霉素的抗性有关这是通过诱导磷脂酰肌醇3-激酶（PI3K）/ Akt /核因子κB（NF-κB）信号通路的激活来实现的

代理获取

本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。

页面导航

摘要
著录项
相似文献
相关主题

摘要

BackgroundBiglycan (BGN) is an extracellular matrix (ECM) protein that regulates the growth of epithelial cells. The mammalian target of rapamycin (mTOR) inhibitor, rapamycin, is a treatment for advanced retinoblastoma. This study aimed to investigate the effects of expression of BGN on the response of human WERI-Rb-1 retinoblastoma cells to rapamycin and to investigate the associated signaling pathways.

机译：背景双糖链蛋白（BGN）是一种调节上皮细胞生长的细胞外基质（ECM）蛋白。雷帕霉素（mTOR）抑制剂的哺乳动物靶标雷帕霉素是晚期视网膜母细胞瘤的治疗方法。这项研究旨在调查BGN的表达对人类WERI-Rb-1视网膜母细胞瘤细胞对雷帕霉素反应的影响，并研究相关的信号传导途径。

著录项

期刊名称 Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
作者
Dong Fang; Zhaoguang Lai; Yan Wang;
展开▼
作者单位

展开▼
年(卷),期 2019(25),-1
年度 2019
页码 6639–6648
总页数 10
原文格式 PDF
正文语种
中图分类
关键词
Biglycan Drug Resistance Neoplasm Phosphatidylinositol 3-Kinases Proto-Oncogene Proteins c-akt Retinoblastoma;

机译：Biglycan;耐药性;肿瘤;磷脂酰肌醇3-激酶;原癌基因蛋白c-akt;成视网膜细胞瘤;

相似文献

外文文献
中文文献
专利

1. Epicatechin induces NF- kappa B, activator protein-1 (AP-1) and nuclear transcription factor erythroid 2p45-related factor-2 (Nrf2) via phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT) and extracellular regulated kinase (ERK) signalling inHepG2 cells. [J] . Granado-Serrano A. B., Martin M. A., Haegeman G., The British Journal of Nutrition . 2010,第2期

机译：表儿茶素通过磷脂酰肌醇3激酶/蛋白激酶B（PI3K / AKT）和细胞外调节激酶（NF-κB，活化蛋白1（AP-1）和核转录因子红细胞2p45相关因子2（Nrf2）诱导。 ERK）在HepG2细胞中发出信号。
2. Epicatechin induces NF- kappaB, activator protein-1 (AP-1) and nuclear transcription factor erythroid 2p45-related factor-2 (Nrf2) via phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT) and extracellular regulated kinase (ERK) signalling inHepG2 cells. [J] . Granado-Serrano A. B., Martin M. A., Haegeman G., The British Journal of Nutrition . 2010,第2期

机译：表儿茶素通过磷脂酰肌醇3激酶/蛋白激酶B（PI3K / AKT）和细胞外调节激酶（ERK）诱导NF-κB，激活蛋白1（AP-1）和核转录因子红细胞2p45相关因子2（Nrf2）。）在HeepG2细胞中发出信号。
3. Epicatechin induces NF-κB, activator protein-1 (AP-1) and nuclear transcription factor erythroid 2p45-related factor-2 (Nrf2) via phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT) and extracellular regulated kinase (ERK) signalling in HepG2 cells [J] . Ana Belén Granado-Serrano, Guy Haegeman, Laura Bravo, The British Journal of Nutrition . 2009,第2期

机译：表儿茶素通过磷脂酰肌醇3激酶/蛋白激酶B（PI3K / AKT）和细胞外调节激酶（ERK）诱导NF-κB，激活蛋白1（AP-1）和核转录因子红细胞2p45相关因子2（Nrf2）。）在HepG2细胞中的信号转导
4. THE E3 UBIQUITIN LIGASE CBL-B REVERSES MULTIDRUG RESISTANCE OF MCF-7/ADR CELLS THROUGH SUPPRESSION OF PI3K/AKT SIGNALING PATHWAY AND DOWN-REGULATION OF P-GLYCOPROTEIN [C] . Ye Zhang, Xiujuan Qu, Xuejun Hu, 2011 Asia-Pacific Conference of tumor biology and medicine . 2011

机译：E3泛素连接酶CBL-B通过抑制PI3K / AKT信号通路和P-糖蛋白下调逆转MCF-7 / ADR细胞的多药耐药性
5. Granulocyte-macrophage colony-stimulating factor-activated signaling pathways in human neutrophils. The mechanism of activation of phosphatidylinositol 3-kinase [D] . Al-Shami, Amin 1998

机译：人类嗜中性粒细胞中的粒细胞-巨噬细胞集落刺激因子激活的信号通路。磷脂酰肌醇3-激酶的激活机制
6. Resveratrol Protects the Myocardium in Sepsis by Activating the Phosphatidylinositol 3-Kinases (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) Pathway and Inhibiting the Nuclear Factor-κB (NF-κB) Signaling Pathway [O] . Xiuling Shang, Kaiyang Lin, Rongguo Yu, 2019

机译：白藜芦醇通过激活雷帕霉素（mTOR）途径的磷脂酰肌醇3-激酶（PI3K）/ AKT /哺乳动物靶标并抑制核因子-κB（NF-κB）信号通路来保护败血症中的心肌
7. Overexpression of Biglycan is Associated with Resistance to Rapamycin in Human WERI-Rb-1 Retinoblastoma Cells by Inducing the Activation of the Phosphatidylinositol 3-Kinases (PI3K)/Akt/Nuclear Factor kappa B (NF-κB) Signaling Pathway [O] . Dong Fang, Zhaoguang Lai, Yan Wang 2019

机译：通过诱导磷脂酰肌醇3-激酶（PI3K）/ Akt /核因子Kappa B（NF-κB）信号通路（NF-κB）信号通路的激活，大甘油的过表达与人WERI-RB-1视网膜细胞瘤细胞中的抗雷帕霉素抗性相关

Overexpression of Biglycan is Associated with Resistance to Rapamycin in Human WERI-Rb-1 Retinoblastoma Cells by Inducing the Activation of the Phosphatidylinositol 3-Kinases (PI3K)/Akt/Nuclear Factor kappa B (NF-κB) Signaling Pathway

摘要

著录项

相似文献

相关主题

期刊订阅