The Correlation Relationship between P14ARF Gene DNA Methylation and Primary Liver Cancer

机译：P14ARF基因DNA甲基化与原发性肝癌的相关性

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BackgroundPrimary liver cancer is a common malignant tumor that causes serious damage to human health. DNA methylation is common in epigenetics. DNA methylation plays an important role in the process of primary liver cancer occurrence and development. The P14^ARF gene is an important tumor suppressor gene. It was found that P14^ARF methylation is associated with the degree of malignancy in multiple tumors. Therefore, this study aimed to investigate the relationship between P14^ARF methylation level and primary liver cancer malignant degree.

机译：背景原发性肝癌是一种常见的恶性肿瘤，会严重损害人类健康。 DNA甲基化在表观遗传学中很常见。 DNA甲基化在原发性肝癌的发生和发展过程中起着重要作用。 P14 ^{ARF 基因是重要的抑癌基因。结果发现，P14 ^{ARF 甲基化与多种肿瘤的恶性程度有关。因此，本研究旨在探讨P14 ^{ARF 甲基化水平与原发性肝癌恶性程度的关系。}}}

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期刊名称 Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
作者
Hui Zhang; Wanpin Nie; Feizhou Huang;
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作者单位

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年(卷),期 2015(21),-1
年度 2015
页码 3077–3082
总页数 6
原文格式 PDF
正文语种
中图分类
关键词
DNA Methylation Pneumonia Mycoplasma Sarcoglycanopathies;

机译：DNA甲基化;肺炎;支原体;肌糖蛋白病;

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专利

1. The Correlation Relationship between P14ARF Gene DNA Methylation and Primary Liver Cancer [J] . Hui Zhang, Wanpin Nie, Feizhou Huang Medical science monitor : . 2015,第1期

机译：P14ARF基因DNA甲基化与原发性肝癌的相关性
2. Promoter methylations of p16INK4a and p14ARF genes in early and advanced gastric cancer. Correlations of the modes of their occurrence with histologic type. [J] . Tsujimoto H, Hagiwara A, Sugihara H, Pathology Research and Practice . 2002,第12期

机译：早期和晚期胃癌中p16INK4a和p14ARF基因的启动子甲基化。它们的发生方式与组织学类型的相关性。
3. DNA methylation of the p14ARF, RASSF1A and APC1A genes as an independent prognostic factor in colorectal cancer patients [J] . Torbj?rn K. Nilsson, Zarah M. L?f-?hlin, Xiao-Feng Sun International journal of oncology . 2012,第1期

机译：p14ARF，RASSF1A和APC1A基因的DNA甲基化是结直肠癌患者的独立预后因素
4. Targeted profiling of 5-(hydroxy)methylcytosine in genomic DNA from human livers: Next-generation sequencing of target enriched DNA reveals unexpectedly high interindividual variability of cytosine methylation and hydroxymethylation [C] . Ivanov Maxim, Ingelman-Sundberg Magnus, Kals Mart, IEEE International Conference on Bioinformatics and Biomedicine . 2014

机译：人类肝脏基因组DNA中5-（羟）甲基胞嘧啶的靶向分析：富含靶DNA的下一代测序揭示了胞嘧啶甲基化和羟甲基化的意料之外的高度个体差异
5. UHRF1 overexpression causes DNA hypomethylation and liver cancer and its loss induces the interferon-gamma pathway. [D] . Mudbhary, Raksha. 2013

机译：UHRF1过表达会导致DNA甲基化不足和肝癌，其丢失会诱导干扰素-γ通路。
6. Relationships between p14ARF Gene Methylation and Clinicopathological Features of Colorectal Cancer: A Meta-Analysis [O] . Zhangjian Zhou, Hao Zhang, Jianguo Lai, -1

机译：p14ARF基因甲基化与大肠癌临床病理特征的关系：Meta分析
7. Correlations of partial and extensive methylation at the p14ARF locus with reduced mRNA expression in colorectal cancer cell lines and clinicopathological features in primary tumors [O] . S. Zheng 2000

机译：P14ARF基因座在结直肠癌细胞系中mRNA表达的偏和广泛甲基化的相关性及原发性肿瘤的临床病理特征

The Correlation Relationship between P14ARF Gene DNA Methylation and Primary Liver Cancer

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