BAY 87–2243 a novel inhibitor of hypoxia-induced gene activation improves local tumor control after fractionated irradiation in a schedule-dependent manner in head and neck human xenografts

摘要

BackgroundThe transcription factor hypoxia-inducible factor-1 (HIF-1) pathway plays an important role in tumor response to cytotoxic treatments. We investigated the effects of a novel small molecule inhibitor of mitochondrial complex I and hypoxia-induced HIF-1 activity BAY-87-2243, on tumor microenvironment and response of human squamous cell carcinoma (hSCC) to clinically relevant fractionated radiotherapy (RT) with and without concomitant chemotherapy.