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Bayesian Assessment of Newborn Brain Maturity from Two-Channel Sleep Electroencephalograms

机译:从两通道睡眠脑电图对新生儿脑成熟进行贝叶斯评估

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摘要

Newborn brain maturity can be assessed by expert analysis of maturity-related patterns recognizable in polysomnograms. Since 36 weeks most of these patterns become recognizable in EEG exclusively, particularly, in EEG recorded via the two central-temporal channels. The use of such EEG recordings enables experts to minimize the disturbance of sleep, preparation time as well as the movement artifacts. We assume that the brain maturity of newborns aged 36 weeks and older can be automatically assessed from the 2-channel sleep EEG as accurately as by expert analysis of the full polysomnographic information. We use Bayesian inference to test this assumption and assist experts to obtain the full probabilistic information on the EEG assessments. The Bayesian methodology is feasibly implemented with Monte Carlo integration over areas of high posterior probability density, however the existing techniques tend to provide biased assessments in the absence of prior information required to explore a model space in detail within a reasonable time. In this paper we aim to use the posterior information about EEG features to reduce possible bias in the assessments. The performance of the proposed method is tested on a set of EEG recordings.
机译:新生儿大脑成熟度可以通过多导睡眠图可识别的成熟度相关模式的专家分析来评估。自36周以来,大多数这些模式在脑电图中都是可识别的,尤其是在通过两个中央时空通道记录的脑电图中。通过使用此类EEG记录,专家可以将睡眠,准备时间以及运动伪影的干扰降到最低。我们假设可以通过2通道睡眠EEG像对完整的多导睡眠图学信息进行专家分析一样准确地自动评估36周岁及以上的新生儿的大脑成熟度。我们使用贝叶斯推断来检验此假设,并协助专家获得有关EEG评估的完整概率信息。贝叶斯方法可以在较高的后验概率密度区域上通过蒙特卡洛积分来实现,但是,在缺乏在合理时间内详细探索模型空间所需的先验信息的情况下,现有技术往往会提供有偏倚的评估。在本文中,我们旨在使用有关脑电图特征的后验信息,以减少评估中可能出现的偏差。在一组EEG记录上测试了所提出方法的性能。

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