A GBM-like V-ATPase signature directs cell-cell tumor signaling and reprogramming via large oncosomes

摘要

BackgroundThe V-ATPase proton pump controls acidification of intra and extra-cellular milieu in both physiological and pathological conditions. We previously showed that some V-ATPase subunits are enriched in glioma stem cells and in patients with poor survival. In this study, we investigated how expression of a GBM-like V-ATPase pump influences the non-neoplastic brain microenvironment.