Oxidative DNA damage is involved in cigarette smoke-induced lung injury in rats

机译：DNA氧化损伤与香烟烟雾引起的大鼠肺损伤有关

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ObjectiveReactive oxygen species (ROS) induced by exogenous toxicants are suggested to be involved in carcinogenesis by oxidative modification of DNA. 8-Hydroxyl-2-deoxyguanosine (8-OHdG) has been considered as a reliable biomarker for oxidative DNA damage both in vivo and in vitro studies. But the effect of smoking on oxidative damage has not yet been fully elucidated.

机译：目的外源性有毒物质诱导的活性氧（ROS）通过DNA的氧化修饰参与致癌作用。 8-羟基-2-脱氧鸟苷（8-OHdG）被认为是体内和体外研究中氧化DNA损伤的可靠生物标志物。但是，吸烟对氧化损伤的影响尚未完全阐明。

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期刊名称 Environmental Health and Preventive Medicine
作者
Zhihai Chen; Dapeng Wang; Xing Liu; Weiwei Pei; Jianxiang Li; Yi Cao; Jie Zhang; Yan An; Jihua Nie; Jian Tong;
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作者单位

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年(卷),期 2015(20),5
年度 2015
页码 318–324
总页数 7
原文格式 PDF
正文语种
中图分类公共卫生工程;
关键词
Cigarette smoke Rats 8-Hydroxy-deoxyguanosine Reactive oxygen species Oxidative stress;

机译：卷烟烟气;大鼠;8-羟基-脱氧鸟苷;活性氧;氧化应激;

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专利

1. Oxidative DNA damage is involved in cigarette smoke-induced lung injury in rats [J] . Zhihai Chen, Dapeng Wang, Xing Liu, Environmental health and preventive medicine . 2015,第5期

机译：DNA氧化损伤与香烟烟雾引起的大鼠肺损伤有关
2. Lung Injury and Lung Cancer Caused by Cigarette Smoke-Induced Oxidative Stress: Molecular Mechanisms and Therapeutic Opportunities Involving the Ceramide-Generating Machinery and Epidermal Growth Factor Receptor [J] . Goldkorn Tzipora, Filosto Simone, Chung Samuel Antioxidants and redox signalling . 2014,第15期

机译：香烟烟雾引起的氧化应激引起的肺损伤和肺癌：涉及神经酰胺产生机制和表皮生长因子受体的分子机制和治疗机会
3. Magnetic bead-based approach to monitoring of cigarette smoke-induced DNA oxidation damage and screening of natural protective compounds [J] . Chen HJ, Chu GH, Cao ZJ, Talanta: The International Journal of Pure and Applied Analytical Chemistry . 2010,第3期

机译：基于磁珠的方法监测香烟烟雾引起的DNA氧化损伤并筛选天然保护性化合物
4. Mice lacking the Cytochrome P450 (CYP)1A2 Gene Display Increased Levels of F2-Isoprostanes, Oxidative DNA Adducts, and Hyperoxic Lung Injury In Vivo [C] . Moorthy B., Wang L., Couroucli X. I., International Conference on Cytochrome P450 . 2009

机译：缺乏细胞色素P450（CYP）1A2基因的小鼠显示出增加的F2 - 依泊司蛋白，氧化DNA加合物和体内高氧肺损伤水平
5. Oxidative damage to DNA: I. Isolation of proteins involved in the recognition of oxidatively damaged DNA. II. Development of next-generation hydroxyl radical footprinting. [D] . Xu, Long. 2009

机译：对DNA的氧化损伤：I.分离与识别氧化损伤的DNA有关的蛋白质。二。下一代羟基自由基足迹的发展。
6. P21-PARP-1 Pathway Is Involved in Cigarette Smoke-Induced Lung DNA Damage and Cellular Senescence [O] . Hongwei Yao, Isaac K. Sundar, Vera Gorbunova, -1

机译：P21-PARP-1途径与香烟烟雾诱导的肺DNA损伤和细胞衰老有关
7. Oxidative DNA damage is involved in cigarette smoke-induced lung injury in rats [O] . Zhihai Chen, Dapeng Wang, Xing Liu, 2015

机译：氧化DNA损伤涉及卷烟烟雾诱导的大鼠肺损伤
8. Formation of Cigarette Smoke-Induced DNA Adducts in the Rat Lung and Nasal Mucosa [R] . Gupta, R. C., Sopori, M. L., Gairola, C. G. 1989

机译：香烟烟雾诱导的大鼠肺和鼻粘膜DNa加合物的形成

Oxidative DNA damage is involved in cigarette smoke-induced lung injury in rats

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