Antisense now makes sense: dual modulation of androgen-dependent transcription by CTBP1-AS

摘要

EMBO J 32 12: 1665–1680 doi:10.1038/emboj.2013.99; published online May032013 [] [] []Recent advances in genomic approaches for exploring the transcriptome have led to the identification of thousands of novel non-coding RNA (ncRNA) transcripts (). While some of these ncRNAs have been implicated in the development and progression of cancer and other human diseases, their underlying mechanisms of action remain largely unknown (). now report the identification of CTBP1-AS, a novel androgen-regulated long ncRNA that promotes prostate cancer growth through sense–antisense repression of the transcriptional co-regulator CTBP1, as well as through the global epigenetic regulation of tumour suppressor genes.