Objectives. To investigate the anti-aging effects of moxa smoke on SAMP8 mice. Methods. Using 2 × 3 factorial design, exposure length (15 or 30 minutes daily), and concentration (low, 5–15 mg/m3; middle, 25–35 mg/m3; high, 85–95 mg/m3), 70 SAMP8 mice were randomly assigned, n = 10/group, to a model group or one of six moxa smoke groups: L1, L2, M1, M2, H1, or H2. Ten SAMR1 mice were used as normal control. Mice in moxa smoke groups were exposed to moxa smoke at respective concentrations and exposure lengths; the model and normal control mice were not exposed. Cerebral 5-HT, DA, and NE levels were determined using ELISA. Results. Compared to normal control, the model group showed a significant decrease in 5-HT, DA, and NE. Compared to model group, 5-HT and NE were significantly higher in groups L2, M1, and M2 and DA was significantly so in L2 and M1. 5-HT, DA, and NE levels were the highest in group M1 among moxa smoke groups. A marked exposure length × concentration interaction was observed for 5-HT, DA, and NE. Conclusion. Moxa smoke increases monoamine neurotransmitter levels, which varies according to concentration and exposure length. Our finding suggests that the middle concentration of moxa smoke for 15 minutes seems the most beneficial.
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机译：目标。要研究艾烟雾对SAMP8小鼠的抗衰老作用。方法。使用2×3因子设计，暴露时间（每天15或30分钟）和浓度（低，5–15 mg / m 3 ；中等，25-35 mg / m 3 < / sup>；高85–95μg / m 3 ），将70只SAMP8小鼠随机分为模型组或六个艾条烟组之一：L1，L2，每组10只，每组n = 10 ，M1，M2，H1或H2。将十只SAMR1小鼠用作正常对照。艾灸烟雾组中的小鼠分别以不同浓度和暴露时间暴露于艾灸烟雾中。模型和正常对照小鼠未暴露。使用ELISA测定脑5-HT，DA和NE水平。结果。与正常对照组相比，模型组显示5-HT，DA和NE明显降低。与模型组相比，L2，M1和M2组的5-HT和NE显着较高，而L2和M1组的DA显着高于模型组。在艾灸吸烟组中，M1组的5-HT，DA和NE水平最高。对于5-HT，DA和NE，观察到显着的暴露长度×浓度相互作用。结论。艾灸烟雾会增加单胺神经递质的水平，视浓度和暴露时间长短而异。我们的发现表明，在15分钟的中浓度艾灸烟雾中似乎是最有益的。
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