Reversal of transforming growth factor-β induced epithelial-to-mesenchymal transition and the ZEB proteins

摘要

BackgroundThe dynamic process of epithelial-to-mesenchymal transition (EMT) is a causal event in kidney fibrosis. This cellular phenotypic transition involves activation of transcriptional responses and remodeling of cellular structures to change cellular function. The molecular mechanisms that directly contribute to the re-establishment of the epithelial phenotype are poorly understood.