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首页> 美国卫生研究院文献>Frontiers in Behavioral Neuroscience >Behavioral Effects of Systemic Infralimbic and Prelimbic Injections of a Serotonin 5-HT2A Antagonist in Carioca High- and Low-Conditioned Freezing Rats
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Behavioral Effects of Systemic Infralimbic and Prelimbic Injections of a Serotonin 5-HT2A Antagonist in Carioca High- and Low-Conditioned Freezing Rats

机译：5-羟色胺5-HT2A拮抗剂全身下肢和前肢注射对Carioca高和低条件冷冻大鼠的行为影响

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摘要

The role of serotonin (5-hydroxytryptamine [5-HT]) and 5-HT2A receptors in anxiety has been extensively studied, mostly without considering individual differences in trait anxiety. Our laboratory developed two lines of animals that are bred for high and low freezing responses to contextual cues that are previously associated with footshock (Carioca High-conditioned Freezing [CHF] and Carioca Low-conditioned Freezing [CLF]). The present study investigated whether ketanserin, a preferential 5-HT2A receptor blocker, exerts distinct anxiety-like profiles in these two lines of animals. In the first experiment, the animals received a systemic injection of ketanserin and were exposed to the elevated plus maze (EPM). In the second experiment, these two lines of animals received microinjections of ketanserin in the infralimbic (IL) and prelimbic (PL) cortices and were exposed to either the EPM or a contextual fear conditioning paradigm. The two rat lines exhibited bidirectional effects on anxiety-like behavior in the EPM and opposite responses to ketanserin. Both systemic and intra-IL cortex injections of ketanserin exerted anxiolytic-like effects in CHF rats but anxiogenic-like effects in CLF rats. Microinjections of ketanserin in the PL cortex also exerted anxiolytic-like effects in CHF rats but had no effect in CLF rats. These results suggest that the behavioral effects of 5-HT2A receptor antagonism might depend on genetic variability associated with baseline reactions to threatening situations and 5-HT2A receptor expression in the IL and PL cortices.>Highlights class="simple" style="list-style-type:none">
  • -CHF and CLF rats are two bidirectional lines that are based on contextual fear conditioning.
  • -CHF rats have a more “anxious” phenotype than CLF rats in the EPM.
  • -The 5-HT2A receptor antagonist ketanserin had opposite behavioral effects in CHF and CLF rats.
  • -Systemic and IL injections either decreased (CHF) or increased (CLF) anxiety-like behavior.
  • -PL injections either decreased (CHF) anxiety-like behavior or had no effect (CLF).
    • 机译：广泛研究了5-羟色胺（5-羟色胺[5-HT]）和5-HT2A受体在焦虑中的作用，但大多数情况下都没有考虑个性焦虑的个体差异。我们的实验室开发了两系动物，它们分别针对先前与足部震颤相关的环境线索（Carioca高条件冷冻[CHF]和Carioca低条件冷冻[CLF]）进行高冻结和低冻结反应。本研究调查了酮康色林（一种优先的5-HT2A受体阻滞剂）是否在这两类动物中表现出明显的焦虑样特征。在第一个实验中，动物接受全身注射酮色林，并暴露于高架迷宫（EPM）中。在第二个实验中，这两行动物在下肢（IL）和前肢（PL）皮质中接受了酮色林的微注射，并暴露于EPM或情境恐惧条件下。两只大鼠品系对EPM中的焦虑样行为表现出双向影响，而对酮色林的反应却相反。酮色林的全身和IL皮层注射均可在CHF大鼠中发挥抗焦虑作用，而在CLF大鼠中具有抗焦虑作用。在PL皮质中显微注射酮色林也对CHF大鼠产生抗焦虑样作用，但对CLF大鼠无作用。这些结果表明，5-HT2A受体拮抗作用的行为效应可能取决于与基线威胁相关的遗传变异和IL和PL皮质中5-HT2A受体的表达。>亮点 class = “ simple” style =“ list-style-type：none”> <！-list-behavior =简单的prefix-word = mark-type = none max-label-size = 1->
  • -CHF和CLF大鼠是基于上下文恐惧条件的两条双向线。
  • -CHF大鼠在EPM中比CLF大鼠更具“焦虑”表型。
  • -5-HT2A受体拮抗剂酮色林在CHF和CLF大鼠中具有相反的行为作用。
  • -全身和IL注射剂量减少（CHF）或
  • -PL注射要么减少（CHF）焦虑样行为，要么没有作用（CLF）。

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