ABSTR 0912 – Proffered Oral Presentation: Systemic Delivery of Liposome-Incorporated Adrenomedullin Receptor (ADMR) Small Interfering RNA Against Tumor and Its Microenvironment Reduced Pancreatic Tumor Growth

摘要

Background:Pancreatic cancer is a major oncologic challenge due to its aggressive growth and metastasis. Our previous study showed that adrenomedullin (AM) is highly expressed in pancreatic cancer and stimulates pancreatic cancer cells leading to increased tumor growth and metastasis. The current study examines the role of specific AM receptors on tumor and cells resembling the tumor microenvironment (human pancreatic stellate - HPSC, human umbilical vein – HUVEC, and mouse lung endothelial cells - MLEC) and investigates the receptor involved in the autocrine role of AM.