Do count-based differential expression methods perform poorly when genes are expressed in only one condition?

摘要

A response to ‘Comprehensive evaluation of differential gene expression analysis methods for RNA-seq data’ by Rapaport F, Khanin R, Liang Y, Pirun M, Krek A, Zumbo P, Mason CE, Socci ND and Betel D in Genome Biology, 2013, 14:R95Electronic supplementary materialThe online version of this article (doi:10.1186/s13059-015-0781-3) contains supplementary material, which is available to authorized users.