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首页> 美国卫生研究院文献>Genetics >Among B-Type Cyclins Only CLB5 and CLB6 Promote Premeiotic S Phase in Saccharomyces cerevisiae
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Among B-Type Cyclins Only CLB5 and CLB6 Promote Premeiotic S Phase in Saccharomyces cerevisiae

机译：在B型细胞周期蛋白中只有CLB5和CLB6促进酿酒酵母中的减数分裂S期。

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The Saccharomyces cerevisiae cyclin is required for premeiotic S phase, meiotic recombination, and successful progression through meiosis. is not essential for mitotic proliferation because – can support DNA replication in mutants. , , and accumulate in cells during meiotic differentiation yet fail to promote premeiotic DNA replication. When expressed under the regulation of the promoter, and accumulate and are active in the early stages of meiotic differentiation but cannot induce premeiotic DNA replication, suggesting that they do not target to the necessary substrates. The hydrophobic patch (HP) residues are important for href="http://www.yeastgenome.org/cgi-bin/locus.fpl?dbid=S000006324" data-ga-action="click_feat_suppl" ref="reftype=extlink&article-id=3296238&issue-id=206306&journal-id=301&FROM=Article%7CFront%20Matter&TO=External%7CLink%7CURI" target="_blank">Clb5 function but this motif alone does not provide the specificity required for href="http://www.yeastgenome.org/cgi-bin/locus.fpl?dbid=S000006324" data-ga-action="click_feat_suppl" ref="reftype=extlink&article-id=3296238&issue-id=206306&journal-id=301&FROM=Article%7CFront%20Matter&TO=External%7CLink%7CURI" target="_blank">Clb5 to induce premeiotic S phase. Domain exchange experiments demonstrated that the amino terminus of href="http://www.yeastgenome.org/cgi-bin/locus.fpl?dbid=S000006324" data-ga-action="click_feat_suppl" ref="reftype=extlink&article-id=3296238&issue-id=206306&journal-id=301&FROM=Article%7CFront%20Matter&TO=External%7CLink%7CURI" target="_blank">Clb5 when fused to href="http://www.yeastgenome.org/cgi-bin/locus.fpl?dbid=S000002314" data-ga-action="click_feat_suppl" ref="reftype=extlink&article-id=3296238&issue-id=206306&journal-id=301&FROM=Article%7CFront%20Matter&TO=External%7CLink%7CURI" target="_blank">Clb3 confers upon href="http://www.yeastgenome.org/cgi-bin/locus.fpl?dbid=S000002314" data-ga-action="click_feat_suppl" ref="reftype=extlink&article-id=3296238&issue-id=206306&journal-id=301&FROM=Article%7CFront%20Matter&TO=External%7CLink%7CURI" target="_blank">Clb3 the ability to induce premeiotic S phase. Chimeric cyclins containing smaller regions of the href="http://www.yeastgenome.org/cgi-bin/locus.fpl?dbid=S000006324" data-ga-action="click_feat_suppl" ref="reftype=extlink&article-id=3296238&issue-id=206306&journal-id=301&FROM=Article%7CFront%20Matter&TO=External%7CLink%7CURI" target="_blank">Clb5 amino terminus displayed reduced ability to activate premeiotic DNA replication despite being more abundant and having greater associated histone H1 kinase activity than endogenous href="http://www.yeastgenome.org/cgi-bin/locus.fpl?dbid=S000006324" data-ga-action="click_feat_suppl" ref="reftype=extlink&article-id=3296238&issue-id=206306&journal-id=301&FROM=Article%7CFront%20Matter&TO=External%7CLink%7CURI" target="_blank">Clb5. These observations suggest that href="http://www.yeastgenome.org/cgi-bin/locus.fpl?dbid=S000006324" data-ga-action="click_feat_suppl" ref="reftype=extlink&article-id=3296238&issue-id=206306&journal-id=301&FROM=Article%7CFront%20Matter&TO=External%7CLink%7CURI" target="_blank">Clb5 has a unique ability to trigger premeiotic S phase and that the amino-terminal region of href="http://www.yeastgenome.org/cgi-bin/locus.fpl?dbid=S000006324" data-ga-action="click_feat_suppl" ref="reftype=extlink&article-id=3296238&issue-id=206306&journal-id=301&FROM=Article%7CFront%20Matter&TO=External%7CLink%7CURI" target="_blank">Clb5 contributes to its specificity and regulates the functions performed by the cyclin–Cdk complex.
机译：酿酒酵母细胞周期蛋白是减数分裂前S期，减数分裂重组和通过减数分裂成功进行所必需的。对于有丝分裂增殖不是必需的，因为–可以支持突变体中的DNA复制。减数分裂过程中在细胞中积累，但不能促进减数分裂前DNA复制。当在启动子的调控下表达时，在减数分裂分化的早期阶段积累并具有活性，但不能诱导减数分裂前的DNA复制，这表明它们并不针对必需的底物。疏水补丁（HP）残基对于href =“ http://www.yeastgenome.org/cgi-bin/locus.fpl?dbid=S000006324” data-ga-action =“ click_feat_suppl” ref =“ reftype = extlink＆article-id = 3296238＆issue-id = 206306＆journal-id = 301＆FROM = Article％7CFront％20Matter＆TO = External％7CLink％7CURI“ target =” _ blank“> Clb5 功能，但仅此基序不能提供所需的特异性href =“ http://www.yeastgenome.org/cgi-bin/locus.fpl?dbid=S000006324” data-ga-action =“ click_feat_suppl” ref =“ reftype = extlink＆article-id = 3296238＆issue-id = 206306＆journal -id = 301＆FROM = Article％7CFront％20Matter＆TO = External％7CLink％7CURI“ target =” _ blank“> Clb5 诱导减数分裂前S期。域交换实验表明，href =“ http://www.yeastgenome.org/cgi-bin/locus.fpl?dbid=S000006324”的氨基末端是data-ga-action =“ click_feat_suppl” ref =“ reftype = extlink＆article-id = 3296238＆issue-id = 206306＆journal-id = 301＆FROM = Article％7CFront％20Matter＆TO = External％7CLink％7CURI“ target =” _ blank“> Clb5 与href =” http：// www。 .yeastgenome.org / cgi-bin / locus.fpl？dbid = S000002314“ data-ga-action =” click_feat_suppl“ ref =” reftype = extlink＆article-id = 3296238＆issue-id = 206306＆journal-id = 301＆FROM = Article％7CFront％20Matter＆TO = External％7CLink％7CURI“ target =” _ blank“> Clb3 赋予href =” http://www.yeastgenome.org/cgi-bin/locus.fpl?dbid=S000002314“数据-action =“ click_feat_suppl” ref =“ reftype = extlink＆article-id = 3296238＆issue-id = 206306＆journal-id = 301＆FROM = Article％7CFront％20Matter＆TO = External％7CLink％7CURI” target =“ _ blank”> Clb3 诱导减数分裂前期S期。包含href =“ http://www.yeastgenome.org/cgi-bin/locus.fpl?dbid=S000006324”较小区域的嵌合细胞周期蛋白。ref =“ reftype = extlink＆article- id = 3296238＆issue-id = 206306＆journal-id = 301＆FROM = Article％7CFront％20Matter＆TO = External％7CLink％7CURI“ target =” _ blank“> Clb5 氨基末端显示出减数分裂前DNA复制的能力降低，尽管其含量更高且比内源性href =“ http://www.yeastgenome.org/cgi-bin/locus.fpl?dbid=S000006324”具有更高的相关组蛋白H1激酶活性ref =“ reftype = extlink＆article-id = 3296238＆issue-id = 206306＆journal-id = 301＆FROM = Article％7CFront％20Matter＆TO = External％7CLink％7CURI“ target =” _ blank“> Clb5 。这些观察结果表明href =“ http://www.yeastgenome.org/cgi-bin/locus.fpl?dbid=S000006324” data-ga-action =“ click_feat_suppl” ref =“ reftype = extlink＆article-id = 3296238＆issue -id = 206306＆journal-id = 301＆FROM = Article％7CFront％20Matter＆TO = External％7CLink％7CURI“ target =” _ blank“> Clb5 具有触发前减数分裂S期的独特能力，并且< a href =“ http://www.yeastgenome.org/cgi-bin/locus.fpl?dbid=S000006324” data-ga-action =“ click_feat_suppl” ref =“ reftype = extlink＆article-id = 3296238＆issue-id = 206306＆journal- id = 301＆FROM = Article％7CFront％20Matter＆TO = External％7CLink％7CURI“ target =” _ blank“> Clb5 有助于其特异性并调节由cyclin–Cdk复合体执行的功能。

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