Odontoblast-like differentiation and mineral formation of pulpsphere derived cells on human root canal dentin in vitro

摘要

BackgroundThe revitalization or regeneration of the dental pulp is a preferable goal in current endodontic research. In this study, human dental pulp cell (DPC) spheres were applied to human root canal samples to evaluate their potential adoption for physiological tissue-like regeneration of the dental root canal by odontoblastic differentiation as well as cell-induced mineral formation.