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The Interlinked Rising Epidemic of Insufficient Sleep and Diabetes Mellitus

机译:睡眠不足和糖尿病的相互联系的上升的流行病

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摘要

For healthy existence, humans need to spend one-third of their time sleeping. Any qualitative or quantitative disturbances in sleep would result in an increased prevalence of obesity, metabolic disorders, diabetes, cardiovascular diseases, and hypertension. The paper aims to highlight the growing global problem of insufficient sleep and its significant impact on the rising incidence of diabetes mellitus. An extensive literature search was done in all major databases for “insufficient sleep” and “Diabetes Mellitus” for this review. Shorter (<6 h) and longer (>9 h) durations of sleep have been adversely related to insulin resistance. Though the relation between insufficient sleep and diabetes mellitus is more or less understood, little is known about how oversleeping or hypersomnia (10–12 h) increases the risk of diabetes. The relationship between sleep disturbances and diabetes is dual-sided, as chronic sleep disturbances would elevate the risk of developing insulin resistance, while diabetes would worsen the quality of sleep. Both the qualitative and quantitative disturbances in sleep significantly increase the risk of developing diabetes, which is supported by numerous community-based and hospital-based epidemiological studies discussed in this review. Obstructive sleep apnea is one of the most common sleep disorders and is characterized by chronic intermittent hypoxia and increased sympathetic activity, thus leading to a higher prevalence of diabetes. Sleep therapy may serve as a low-cost method for fighting against the rising epidemic of diabetes.
机译:为了健康存在,人类需要花费三分之一的时间睡觉。睡眠中任何定性或定量的干扰都会导致肥胖,代谢紊乱,糖尿病,心血管疾病和高血压的患病率增加。本文旨在强调日益严重的全球睡眠不足问题及其对糖尿病发病率上升的重大影响。在所有主要数据库中,针对该评价,针对“睡眠不足”和“糖尿病”进行了广泛的文献检索。较短的睡眠时间(<6小时)和较长的时间(> 9小时)与胰岛素抵抗相关。尽管人们或多或少地了解了睡眠不足与糖尿病之间的关系,但对于过度睡眠或睡眠不足(10-12小时)如何增加患糖尿病的风险知之甚少。睡眠障碍和糖尿病之间的关系是双向的,因为慢性睡眠障碍会增加发生胰岛素抵抗的风险,而糖尿病会恶化睡眠质量。睡眠的定性和定量紊乱都显着增加了患糖尿病的风险,本综述中讨论的众多基于社区和基于医院的流行病学研究都支持这种情况。阻塞性睡眠呼吸暂停是最常见的睡眠障碍之一,其特征是慢性间歇性缺氧和交感神经活动增加,从而导致糖尿病患病率更高。睡眠疗法可以作为一种抗击糖尿病流行病的低成本方法。

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