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Characterization of hepatitis C virus resistance to grazoprevir reveals complex patterns of mutations following on-treatment breakthrough that are not observed at relapse

机译：丙型肝炎病毒对grazoprevir的耐药性表征揭示了在治疗突破后出现的复杂的突变模式在复发时未观察到

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PurposeA detailed analysis of hepatitis C virus (HCV) resistance-associated substitutions (RASs) is required to understand why people fail direct-acting antiviral therapies. This study was conducted to assess RASs in an analysis of 2 trials evaluating the second-generation NS3/4A protease inhibitor grazoprevir (GZR) in combination with peginterferon/ribavirin.

机译：目的需要详细分析丙型肝炎病毒（HCV）耐药性相关替代（RASs），以了解人们为何无法直接使用抗病毒治疗。这项研究是在对2项评估第二代NS3 / 4A蛋白酶抑制剂grazoprevir（GZR）与聚乙二醇干扰素/利巴韦林联用的试验的分析中评估RAS的。

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期刊名称 Infection and Drug Resistance
作者
David Bonsall; Stuart Black; Anita YM Howe; Robert Chase; Paul Ingravallo; Irene Pak; Anthony Brown; David A Smith; Rory Bowden; Eleanor Barnes;
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作者单位

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年(卷),期 2018(11),-1
年度 2018
页码 1119–1135
总页数 17
原文格式 PDF
正文语种
中图分类药学;
关键词
next-generation sequencing NS3/4A protease inhibitor resistance-associated substitution virologic failure;

机译：下一代测序;NS3 / 4A蛋白酶抑制剂;耐药相关替代;病毒学衰竭;

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1. Characterization of hepatitis C virus resistance to grazoprevir reveals complex patterns of mutations following on-treatment breakthrough that are not observed at relapse [J] . David Bonsall, Stuart Black, Anita YM Howe, Infection and Drug Resistance . 2018,第9期

机译：丙型肝炎病毒对grazoprevir的耐药性表征揭示了治疗突破后突变的复杂模式，在复发时未观察到
2. Intracellular levels of hepatitis B virus DNA and mutational patterns of the polymerase gene of hepatitis B virus in peripheral blood mononuclear cells of patients with lamivudine or telbivudine resistance [J] . Zhang Xiaoguo, Liu Lu, Xu Wansu, Experimental and therapeutic medicine . 2015,第3期

机译：拉米夫定或替比夫定耐药患者外周血单个核细胞中乙型肝炎病毒DNA的细胞内水平和乙型肝炎病毒聚合酶基因的突变型
3. Novel patterns of amino acid mutations in the hepatitis B virus polymerase in association with resistance to lamivudine therapy in japanese patients with chronic hepatitis B. [J] . Ogata N, Fujii K, Takigawa S, Journal of Medical Virology . 1999,第3期

机译：在日本慢性乙型肝炎患者中，乙型肝炎病毒聚合酶中氨基酸突变的新模式与对拉米夫定治疗的耐药性相关。
4. Prediction of human immunodeficiency virus type 1 drug resistance: Representation of target sequence mutational patterns via an n-grams approach [C] . Masso Majid 2012 IEEE International Conference on Bioinformatics and Biomedicine. . 2012

机译：预测人类1型免疫缺陷病毒耐药性：通过n-grams方法表示靶序列突变模式
5. The Functional Study of HCC-associated Mutations on Hepatitis B Virus. [D] . Li, Man Shan. 2010

机译：HCC相关突变对乙型肝炎病毒的功能研究。
6. Intracellular levels of hepatitis B virus DNA and mutational patterns of the polymerase gene of hepatitis B virus in peripheral blood mononuclear cells of patients with lamivudine or telbivudine resistance [O] . XIAOGUO ZHANG, LU LIU, WANSU XU, -1

机译：拉米夫定或替比夫定耐药患者外周血单个核细胞中乙型肝炎病毒DNA的细胞内水平和乙型肝炎病毒聚合酶基因的突变模式
7. Intracellular levels of hepatitis B virus DNA and mutational patterns of the polymerase gene of hepatitis B virus in peripheral blood mononuclear cells of patients with lamivudine or telbivudine resistance [O] . XIAOGUO ZHANG, LU LIU, WANSU XU, 2014

机译：肝炎患者外周血单个核细胞的乙型肝炎病毒DNA和丙型肝炎病毒的聚合酶突变模式的细胞内水平的细胞凋亡水平

Characterization of hepatitis C virus resistance to grazoprevir reveals complex patterns of mutations following on-treatment breakthrough that are not observed at relapse

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