Higher Frequency of HIV-1 Drug Resistance and Increased NucleosideReverse Transcriptase Inhibitor Mutations among the HIV-1 PositiveAntiretroviral Therapy–Naïve patients Coinfected With Mycobacteriumtuberculosis Compared With Only HIV Infection inIndia

摘要

Background:Emergence of human immunodeficiency virus (HIV) drug resistance mutations prior to highly active antiretroviral therapy is a serious problem in clinical management of HIV/AIDS. Risk factors for appearance of drug resistance mutations are not known. We hypothesize that Mycobacterium tuberculosis infection may contribute to rapid emergence of such mutations in antiretroviral therapy–naïve patients.