Tuberculosis has, in a short span of time, become a major health problem in the third world or developing countries like India. In view of this, a retrospective study was conducted to study Adenosine deaminase activity in serum and pleural fluid in patients affected with Pulmonary Tuberculosis and other common non-tubercular chronic respiratory diseases. The study was carried out on 100 patients suffering from various pulmonary disorders, between January 2002 and August 2002. Thirty-five normal healthy individuals were included as control subjects. ADA estimation was done by sensitive colorimetric method. The study revealed that the serum ADA activity was higher in patients of tuberculous pulmonary and pleural diseases and non-tuberculous pulmonary diseases than in control subjects. The mean serum ADA activity in the patients’ group was 35.5±6.93 u/l as compared to 16.20±2.85 u/l in control group, showing a highly significant (P≪0.001) difference. ADA activity was highest in tuberculous pleuropulmonary diseases. The pleural fluid ADA activity was higher in pyogenic pleural effusion than in tuberculous pleural effusion.
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机译:在很短的时间内,结核病已成为第三世界或印度等发展中国家的主要健康问题。有鉴于此,进行了一项回顾性研究,以研究肺结核和其他常见的非结核性慢性呼吸道疾病患者的血清和胸水中的腺苷脱氨酶活性。该研究于2002年1月至2002年8月期间对100例患有各种肺部疾病的患者进行了研究。将35例正常健康个体作为对照组。 ADA估计是通过敏感的比色法完成的。研究表明,结核性肺和胸膜疾病和非结核性肺疾病患者的血清ADA活性高于对照组。患者组的平均血清ADA活性为35.5±6.93 u / l,而对照组为16.20±2.85 u / l,差异有统计学意义(P≪0.001)。在结核性胸膜肺疾病中,ADA活性最高。化脓性胸腔积液中的胸水ADA活性高于结核性胸腔积液。
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