The clinical utility of anti-chromatin antibodies as measured by BioPlex 2200 in the diagnosis of systemic lupus erythematosus versus other rheumatic diseases

摘要

BackgroundThe detection of autoantibodies is indispensable to systemic lupus erythematosus (SLE). Bioplex 2200 ANA screen is a multiplex immunoassay system that allows simultaneous determination of autoantibodies to extractable nuclear antigens (ENA) including anti-chromatin antibodies (ACAs). However, the clinical significance of the ACAs by this new method in SLE patients has not been studied in comparison with other rheumatic disorders. We performed a retrospective study of patients with rheumatic diseases to assess the diagnostic value of the ACAs by Bioplex 2200 method in SLE.