Validating intramyocardial bone marrow stem cell therapy in combination with coronary artery bypass grafting the PERFECT Phase III randomized multicenter trial: study protocol for a randomized controlled trial

摘要

BackgroundFor the last decade continuous efforts have been made to translate regenerative cell therapy protocols in the cardiovascular field from ‘bench to bedside’. Successful clinical introduction, supporting safety, and feasibility of this new therapeutic approach, led to the initiation of the German, Phase III, multicenter trial - termed the PERFECT trial (ClinicalTrials.gov Identifier: ), in order to evaluate the efficacy of surgical cardiac cell therapy on left ventricular function.