Advances in blood–brain barrier modeling in microphysiological systems highlight critical differences in opioid transport due to cortisol exposure

摘要

Fluorescent imaging of primary human BMECs in the original versus new NVU design. Images were acquired 3 days after seeding and are representative of multiple devices. The transition from a polycarbonate membrane in the original NVU to a PET membrane (which is thinner and more optically transparent) in the updated NVU improves the ability to image cells in real-time