Preservation Solutions for Kidney Transplantation: History Advances andMechanisms

摘要

Solid organ transplantation was one of the greatest medical advances during the past fewdecades. Organ preservation solutions have been applied to diminish ischemic/hypoxicinjury during cold storage and improve graft survival. In this article, we provide ageneral review of the history and advances of preservation solutions for kidneytransplantation. Key components of commonly used solutions are listed, and effectivesupplementations for current available preservation solutions are discussed. At cellularand molecular levels, further insights were provided into the pathophysiologicalmechanisms of effective ingredients against ischemic/hypoxic renal injury during coldstorage. We pay special attention to the cellular and molecular events duringtransplantation, including ATP depletion, acidosis, mitochondrial dysfunction, oxidativestress, inflammation, and other intracellular mechanisms.