We examined the birth prevalence of cleft lip with or without cleft palate and of isolated cleft palate in British Columbia between 1952 and 1986 using the data of the BC Health Surveillance Registry. The rates fluctuated over the study period, but linear trend analysis showed no increase or decrease for cleft lip with or without cleft palate; however, there was a significant increase for isolated cleft palate, attributed to improved ascertainment around 1963-66. Given the possible effects of newer agents used in both silviculture and agriculture, as well as the general concern over drugs and other environmental agents, such a long-term monitoring program is important. Furthermore, if significant clustering occurs, good background data are essential for comparison. The general public's perception is that the rates of birth defects are increasing. Our findings should give some reassurance with respect to orofacial clefts.
展开▼
机译:我们使用BC Health Surveillance Registry的数据,检查了1952年至1986年间在不列颠哥伦比亚省有或没有without裂的唇裂和孤立的c裂的出生率。率在研究期间内波动,但线性趋势分析显示有或没有without裂的唇裂没有增加或减少;然而,孤立的963裂明显增加,这归因于1963-66年左右的确定性改善。鉴于在造林和农业中使用更新剂的可能产生的影响,以及对药物和其他环境因素的普遍关注,这样的长期监测计划很重要。此外,如果发生明显的聚类,则良好的背景数据对于进行比较至关重要。公众的看法是,出生缺陷的比率正在增加。我们的发现应该使人对口面部裂痕有所放心。
展开▼