Stimulant Effects of a Sulfonamide Preparation Sulfaphenazole on the Central Nervous System in Rats

摘要

Sulfaphenazole (Orisul), which had been reported to cause a convulsant syndrome in young European children, lowered the electroshock threshold in rats when administered in the form of tablets or suspension. This effect was not obtained with a sample of sulfaphenazole pure drug or with several other long-acting oral sulfonamide preparations, but was obtained with a mixture of impurities which had been found in the same lot of Orisul that had reportedly caused the convulsant syndrome. A change in the method of manufacture now provides a product which is free from these impurities.