HYPERSENSITIVITY TO HOUSE DUST—A Preliminary Report on Treatment of Children with Antigens at Two Different Dosage Levels

摘要

Two comparable groups of children with allergic sensitivity primarily to house dust were treated respectively with low (1:1,000,000) and high (1:100) dilutions of Endo house-dust extract. In the two groups there were 47 patients with asthma, 5 with chronic allergic rhinitis, and 10 with both.After an average of 16 to 18 months of injection treatment, good to excellent results were obtained by 75 per cent of the patients on low dosage and 80 per cent on high dosage. Change of dosage from low to high in five cases, and from high to low in five others, made no perceptible difference in results. Continuous and regular treatment seemed to be more important than the size of dose.The apparent effectiveness of small doses of dust extract may be due to the polysaccharide nature of the material which persists as an active antigen in the tissues.