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Nanomolar potency and selectivity of a Ca2+ release-activated Ca2+ channel inhibitor against store-operated Ca2+ entry and migration of vascular smooth muscle cells

机译：Ca2 +释放激活的Ca2 +通道抑制剂对储存操作的Ca2 +进入和迁移的血管平滑肌细胞的纳摩尔效能和选择性

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BACKGROUND AND PURPOSEThe aim was to advance the understanding of Orai proteins and identify a specific inhibitor of the associated calcium entry mechanism in vascular smooth muscle cells (VSMCs).

机译：背景和目的目的是增进对Orai蛋白的了解，并确定血管平滑肌细胞（VSMC）中相关钙进入机制的特异性抑制剂。

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期刊名称 British Journal of Pharmacology and Chemotherapy
作者
Jing Li; Lynn McKeown; Ogooluwa Ojelabi; Martin Stacey; Richard Foster; David ORegan; Karen E Porter; David J Beech;
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作者单位

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年(卷),期 2011(164),2
年度 2011
页码 382–393
总页数 12
原文格式 PDF
正文语种
中图分类药学;
关键词
vascular smooth muscle migration calcium channel store-operated calcium entry platelet-derived growth factor chemical blockade;

机译：血管平滑肌;迁移;钙通道;钙库操纵的钙进入;血小板衍生的生长因子;化学封锁;

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专利

1. Trp-His, a vasorelaxant di-peptide, can inhibit extracellular Ca2+ entry to rat vascular smooth muscle cells through blockade of dihydropyridine-like L-type Ca2+ channels. [J] . Wang Z, Watanabe S, Kobayashi Y, Peptides: An International Journal . 2010,第11期

机译：Trp-His是一种血管舒张剂二肽，可通过阻断二氢吡啶样L型Ca2 +通道来抑制细胞外Ca2 +进入大鼠血管平滑肌细胞。
2. Ginsenoside-Rd from panax notoginseng blocks Ca2+ influx through receptor- and store-operated Ca2+ channels in vascular smooth muscle cells. [J] . Guan YY, Zhou JG, Zhang Z, European Journal of Pharmacology: An International Journal . 2006,第1a3期

机译：来自三七的人参皂苷-Rd阻断Ca2 +通过血管平滑肌细胞中受体和存储操纵的Ca2 +通道的流入。
3. Contribution of Cav1.2 Ca2+ channels and store-operated Ca2+ entry to pig urethral smooth muscle contraction [J] . Benjamin E. Reinbetski, Kenton M. Sers, Bernard T. Drumm American Journal of Physiology . 2020,第2aPta2期

机译：CAV1.2 CA2 +通道的贡献和商店运营的CA2 +进入猪尿道平滑肌收缩
4. Simulation of Mechanical Force in Skeletal Muscle According to the Intracellular Ca2+ Concentration Level [C] . M. Karami, J. Grasa, B. Calvo, National Conference on Biomedical Engineering . 2017

机译：根据细胞内Ca 2 +浓度水平的骨骼肌机械力模拟
5. Coagulation factor XⅠinduces Ca2+ response and accelerates cell migration in vascular smooth muscle cells via proteinase-activated receptor 1 [D] . 劉文華 2019

机译：凝血因子XⅠ通过蛋白酶激活受体1诱导Ca2 +反应并加速血管平滑肌细胞的细胞迁移
6. Activity of Ca2+ -activated Cl- channels contributes to regulating receptor- and store-operated Ca2+ entry in human pulmonary artery smooth muscle cells [O] . Aya Yamamura, Hisao Yamamura, Amy Zeifman, 2011

机译：Ca2 +激活的Cl-通道的活性有助于调节人肺动脉平滑肌细胞中受体和存储操纵的Ca2 +进入
7. Nanomolar potency and selectivity of a Ca2+ release-activated Ca2+ channel inhibitor against store-operated Ca2+ entry and migration of vascular smooth muscle cells [O] . Li, Jing, McKeown, Lynn, Ojelabi, Ogooluwa, 2011

机译：Ca2 +释放激活的Ca2 +通道抑制剂对储库操作的Ca2 +进入和血管平滑肌细胞迁移的纳摩尔效能和选择性

Nanomolar potency and selectivity of a Ca2+ release-activated Ca2+ channel inhibitor against store-operated Ca2+ entry and migration of vascular smooth muscle cells

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