Hydrogen sulfide lowers hyperhomocysteinemia dependent on cystathionine γ lyase S‐sulfhydration in ApoE‐knockout atherosclerotic mice

机译：硫化氢可降低ApoE基因敲除的动脉粥样硬化小鼠中胱硫醚γ裂解酶S硫酸化的高同型半胱氨酸血症

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Background and PurposeHydrogen sulfide donors can block the cardiovascular injury of hyperhomocysteinemia. H2S also lowers serum homocysteine in rats with mild hyperhomocysteinemia, but the pharmacological mechanism is unknown. The present study investigated the mechanism(s) involved.

机译：背景与目的硫化氢供体可以阻断高同型半胱氨酸血症的心血管损伤。 H2S还能降低轻度高同型半胱氨酸血症大鼠的血清同型半胱氨酸，但其药理机制尚不清楚。本研究调查了涉及的机制。

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期刊名称 British Journal of Pharmacology and Chemotherapy
作者
Jinhui Fan; Fengjiao Zheng; Shuangyue Li; Cangting Cui; Shan Jiang; Jun Zhang; Jun Cai; Qinghua Cui; Jichun Yang; Xinjing Tang; Guoheng Xu; Bin Geng;
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作者单位

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年(卷),期 2019(176),17
年度 2019
页码 3180–3192
总页数 13
原文格式 PDF
正文语种
中图分类药学;
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1. Sulfhydration of perilipin 1 is involved in the inhibitory effects of cystathionine gamma lyase/hydrogen sulfide on adipocyte lipolysis [J] . Biochemical and Biophysical Research Communications . 2020,第3期

机译：Perilipin 1的硫化物参与了胱硫脲γ脱氨酸酶/硫化物对脂肪细胞脂肪解的抑制作用
2. Cystathionine gamma-Lyase-Hydrogen Sulfide Induces Runt-Related Transcription Factor 2 Sulfhydration, Thereby Increasing Osteoblast Activity to Promote Bone Fracture Healing [J] . Zheng Yang, Liao Feng, Lin Xianjuan, Antioxidants and redox signalling . 2017,第11期

机译：胱硫胺γ-裂解酶 - 硫化氢诱导裂通相关的转录因子2硫化物，从而增加成骨细胞活性以促进骨折愈合
3. Cystathionine gamma lyase-hydrogen sulfide increases peroxisome proliferator-activated receptor gamma activity by sulfhydration at C139 site thereby promoting glucose uptake and lipid storage in adipocytes [J] . Cai Junyan, Shi Xiaoqin, Wang Huamin, Biochimica et Biophysica Acta. Molecular and cell biology of Lipids . 2016,第5期

机译：胱硫醚γ裂解酶-硫化氢通过在C139位点处的巯基化作用来增加过氧化物酶体增殖物激活的受体γ的活性，从而促进脂肪细胞中葡萄糖的吸收和脂质的储存
4. The role of experimental model of atherosclerosis: apoE-knockout mice in developing new drugs against atherosclerosis [C] . Jawien J. International Congress on Coronary Artery Disease. . 2013

机译：动脉粥样硬化的实验模型的作用：Apoe-Nockout小鼠在制育新药物对动脉粥样硬化的作用
5. Investigation of the determinants of reaction specificity in the pyridoxal 5'-phosphate dependent enzymes cystathionine beta-lyase and cystathionine gamma-lyase [D] . Farsi, Ali 2007

机译：吡ido醛5'-磷酸依赖性酶胱硫醚β-裂合酶和胱硫醚γ-裂合酶中反应特异性决定因素的研究
6. Cystathionine γ-Lyase–Hydrogen Sulfide Induces Runt-Related Transcription Factor 2 Sulfhydration Thereby Increasing Osteoblast Activity to Promote Bone Fracture Healing [O] . Yang Zheng, Feng Liao, Xianjuan Lin, -1

机译：胱硫醚γ-裂解酶-硫化氢诱导与矮子相关的转录因子2硫化从而增加成骨细胞活性以促进骨骨折愈合
7. S-3-Carboxypropyl-l-cysteine specifically inhibits cystathionine γ-lyase–dependent hydrogen sulfide synthesis [O] . Pramod K. Yadav, Victor Vitvitsky, Hanseong Kim, 2019

机译：S-3-羧丙基-1-半胱氨酸特异性抑制胱硫氨酸氨酰γ-裂解酶依赖性硫化氢合成

Hydrogen sulfide lowers hyperhomocysteinemia dependent on cystathionine γ lyase S‐sulfhydration in ApoE‐knockout atherosclerotic mice

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