The anti‐migraine component of butterbur extracts isopetasin desensitizes peptidergic nociceptors by acting on TRPA1 cation channel

摘要

Background and PurposeThe mechanism of the anti‐migraine action of extracts of butterbur [Petasites hybridus (L.) Gaertn.] is unknown. Here, we investigated the ability of isopetasin, a major constituent of these extracts, to specifically target TRPA1 channel and to affect functional responses relevant to migraine.