Effects by silodosin on the partially obstructed rat ureter in vivo and on human and rat isolated ureters

机译：西洛多辛对体内部分阻塞的大鼠输尿管以及对人和大鼠离体输尿管的影响

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摘要

Background and Purposeα1-adrenoceptor (-AR) antagonists may facilitate ureter stone passage in humans. We aimed to study effects by the α1A-AR selective antagonist silodosin (compared to tamsulosin and prazosin) on ureter pressures in a rat model of ureter obstruction, and on contractions of human and rat isolated ureters.

机译：背景与目的α1-肾上腺素能受体（-AR）拮抗剂可促进输尿管结石通过人体。我们旨在研究α1A-AR选择性拮抗剂西洛多辛（与坦索罗辛和吡唑嗪相比）对输尿管梗阻大鼠模型中输尿管压力以及人和大鼠离体输尿管收缩的影响。

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期刊名称 British Journal of Pharmacology and Chemotherapy
作者
L Villa; R Buono; N Fossati; P Rigatti; F Montorsi; F Benigni; P Hedlund;
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作者单位

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年(卷),期 2013(169),1
年度 2013
页码 230–238
总页数 9
原文格式 PDF
正文语种
中图分类药学;
关键词
ureter urolithiasis pressure in vivo α1A-adrenoceptor antagonist uroselectivity;

机译：输尿管;尿路结石;压力;体内;α1A-肾上腺素能受体;拮抗剂;尿液选择性;

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专利

1. Cyclooxygenase type 2 is increased in obstructed rat and human ureter and contributes to pelvic pressure increase after obstruction [J] . R N?rregaard, B L Jensen, S O Topcu, Kidney international. . 2006,第5期

机译：2型环氧合酶在阻塞的大鼠和输尿管中增加，并导致阻塞后骨盆压力升高
2. Cyclooxygenase type 2 is increased in obstructed rat and human ureter and contributes to pelvic pressure increase after obstruction [J] . R N?rregaard, B L Jensen, S O Topcu, Kidney international. . 2006,第5期

机译：2型环氧合酶在阻塞的大鼠和输尿管中增加，并导致阻塞后骨盆压力升高
3. Atorvastatin ameliorates tissue damage of obstructed ureter in rats. [J] . Chuang YH, Chuang WL, Huang SP, Life sciences . 2011,第21a22期

机译：阿托伐他汀改善大鼠输尿管阻塞的组织损伤。
4. Variable Pulsewidth Erbium: YAG Laser Ablation of the Ureter and Urethra In Vitro and In Vivo: Optimization of the Laser Fluence, Pulse Duration, and Pulse Repetition Rate [C] . Nathaniel M. Fried, Zelalem Tesfaye, Albert M. Ong, Conference on lasers in surgery: Advanced characterization, therapeutics, and systems . 2004

机译：可变脉冲百年erbium：在体外和体内的输尿管和尿道的YAG激光烧蚀：优化激光器流量，脉冲持续时间和脉冲重复率
5. The Effects of Sumac on Saturated Fat-induced Inflammation in Human Vascular Smooth Muscle Cells and Isolated Mesenteric Arteries from Rats [D] . Barberes, Julia. 2018

机译：Sumac对饱和脂肪诱导的人血管平滑肌细胞和大鼠离体肠系膜动脉炎症的影响
6. Mr Allans Case of Obstructed Ureter with Ulceration of the Kidney and Abscess [O] . Robert Allan Esq. 1837

机译：艾伦先生的输尿管阻塞病例伴有肾脏溃疡和脓肿
7. Effects by silodosin on the partially obstructed rat ureter in vivo and on human and rat isolated ureters [O] . Villa, L., Buono, R., Fossati, N., 2013

机译：西洛多辛对体内和人和大鼠孤立输尿管部分阻塞大鼠输尿管的影响

Effects by silodosin on the partially obstructed rat ureter in vivo and on human and rat isolated ureters

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