Impaired neoangiogenesis in β2–adrenoceptor gene-deficient mice: restoration by intravascular human β2–adrenoceptor gene transfer and role of NFκB and CREB transcription factors

摘要

BACKGROUND AND PURPOSEThere is much evidence supporting the role of β2-adrenoceptors (β2AR) in angiogenesis but the mechanisms underlying their effects have not been elucidated. Hence, we studied post-ischaemic angiogenesis in the hindlimb (HL) of β2AR knock-out mice (β2AR−/−) in vivo and explored possible molecular mechanisms in vitro.