Biodistribution pharmacokinetics and metabolism of interleukin-1 receptor antagonist (IL-1RA) using 18F-IL1RA and PET imaging in rats

摘要

BACKGROUND AND PURPOSEPositron emission tomography (PET) has the potential to improve our understanding of the preclinical pharmacokinetics and metabolism of therapeutic agents, and is easily translated to clinical studies in humans. However, studies involving proteins radiolabelled with clinically relevant PET isotopes are currently limited. Here we illustrate the potential of PET imaging in a preclinical study of the biodistribution and metabolism of ¹⁸F-labelled IL-1 receptor antagonist ([¹⁸F]IL-1RA) using a novel [¹⁸F]-radiolabelling technique.