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Pharmacological characterization of recombinant NR1/NR2A NMDA receptors with truncated and deleted carboxy termini expressed in Xenopus laevis oocytes

机译：在非洲爪蟾卵母细胞中表达的具有截短和缺失的羧基末端的重组NR1 / NR2A NMDA受体的药理特性

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Background and purpose:The carboxy terminal domain (CTD) of NR2 N-methyl-d-aspartate receptor (NMDAR) subunits interacts with numerous scaffolding and signal transduction proteins. Mutations of this region affect trafficking and downstream signalling of NMDARs. This study determines to what extent characteristic pharmacological properties of NR2A-containing NMDARs are influenced by this key functional domain.

机译：背景与目的：NR2 N-甲基-d-天冬氨酸受体（NMDAR）亚基的羧基末端结构域（CTD）与众多支架和信号转导蛋白相互作用。该区域的突变影响NMDAR的运输和下游信号传导。这项研究确定了此关键功能域在多大程度上影响了含NR2A的NMDARs的特征性药理特性。

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期刊名称 British Journal of Pharmacology and Chemotherapy
作者
CA Puddifoot; PE Chen; R Schoepfer; DJA Wyllie;
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作者单位

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年(卷),期 2009(156),3
年度 2009
页码 509–518
总页数 10
原文格式 PDF
正文语种
中图分类药学 ;
关键词
NMDA glutamate glycine memantine oocyte two electrode voltage clamp electrophysiology ion channel;

机译：NMDA;谷氨酸;甘氨酸;美金刚;卵母细胞;两个电极电压钳;电生理;离子通道;

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专利

1. Mg2+ and memantine block of rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed in Xenopus laevis oocytes. [J] . Wrighton DC, Baker EJ, Chen PE The Journal of Physiology . 2008 ,第1期

机译：大鼠重组NMDA受体的Mg2 +和美金刚烷受体含有在非洲爪蟾卵母细胞中表达的嵌合NR2A / 2D亚基。
2. Modulation of glycine potency in rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed in Xenopus laevis oocytes. [J] . Chen PE, Geballe MT, Katz E The Journal of Physiology . 2008 ,第1期

机译：对非洲重组爪蟾卵母细胞中表达的含有嵌合NR2A / 2D亚基的大鼠重组NMDA受体中甘氨酸效能的调节。
3. Local anaesthetics inhibit signalling of human NMDA receptors recombinantly expressed in Xenopus laevis oocytes: role of protein kinase C [J] . K. Hahnenkamp1, M. E. Durieux3, A. Hahnenkamp2, British Journal of Anaesthesia . 2006 ,第1期

机译：局麻药抑制非洲爪蟾卵母细胞中重组表达的人NMDA受体的信号传导：蛋白激酶C的作用
4. Volatile anesthetics, enflurane, isoflurane inhibit 5-hydroxytryptamine type 2C receptors expressed in Xenopus oocytes [C] . Takafumi Horishita, Munehiro Shiraishi, Kouichiro Minam International Conference on Basic and Systemic Mechanisms of Anesthesia . 2005

机译：挥发性麻醉剂，烯丙烷，异氟醚抑制在外爪蟾卵母细胞中表达的5-羟基对胺型2C受体
5. Pharmacological characterization of rat brain excitatory amino acid receptors expressed in Xenopus oocytes. [D] . Verdoorn, Todd Allen. 1988

机译：在非洲爪蟾卵母细胞中表达的大鼠脑兴奋性氨基酸受体的药理特性。
6. Modulation of glycine potency in rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed in Xenopus laevis oocytes [O] . Philip E Chen, Matthew T Geballe, Elyse Katz, 2008

机译：在非洲爪蟾卵母细胞中表达的含有嵌合NR2A / 2D亚基的大鼠重组NMDA受体中甘氨酸效价的调节
7. Pharmacological characterization of recombinant NR1/NR2A NMDA receptors with truncated and deleted carboxy termini expressed in Xenopus laevis oocytes [O] . Puddifoot, CA, Chen, PE, Schoepfer, R, 2009

机译：在非洲爪蟾卵母细胞中表达的具有截短和缺失的羧基末端的重组NR1 / NR2A NMDA受体的药理特性
8. Characterization of Human Phagocytic Cell Receptors for C5A and PlateletActivating Factor Expressed in Xenopus Oocytes [R] . Murphy, P. M., Gallin, E. K., Tiffany, H. L. 1990

机译：非洲爪蟾卵母细胞中人类吞噬细胞受体C5a和血小板活化因子的表征

Pharmacological characterization of recombinant NR1/NR2A NMDA receptors with truncated and deleted carboxy termini expressed in Xenopus laevis oocytes

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