A novel diketopiperazine improves functional recovery given after the onset of 6-OHDA-induced motor deficit in rats

机译：新型二酮哌嗪可改善6-OHDA诱导的大鼠运动功能障碍发作后的功能恢复

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Background and purpose:Cyclo-L-glycyl-L-2-allylproline (NNZ-2591), a modified diketopiperazine, is neuroprotective and improves long-term function after hypoxic-ischaemic brain injury in rats. The present studies were designed to examine both the neuroprotective and neurotrophic actions of NNZ-2591 on neurochemical and behavioural changes in a rat model of Parkinson's disease.

机译：背景与目的：修饰的二酮哌嗪（Cycle-L-glycyl-L-2-allylproline）（NNZ-2591）具有神经保护作用，并改善缺氧缺血性脑损伤后的长期功能。本研究旨在检查NNZ-2591对帕金森氏病大鼠模型中神经化学和行为变化的神经保护作用和神经营养作用。

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期刊名称 British Journal of Pharmacology and Chemotherapy
作者
RVM Krishnamurthi; S Mathai; AH Kim; R Zhang; J Guan;
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作者单位

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年(卷),期 2009(156),4
年度 2009
页码 662–672
总页数 11
原文格式 PDF
正文语种
中图分类药学;
关键词
diketopiperazine functional recovery forelimb akinesia Parkinsons disease rats and 6-OHDA lesion;

机译：二酮哌嗪;功能恢复;前肢运动障碍;帕金森氏病;大鼠和6-OHDA病变;

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专利

1. Exercise improves motor deficits and alters striatal GFAP expression in a 6-OHDA-induced rat model of Parkinson's disease. [J] . Márcio Ferreira Dutra, Mariane Jaeger, Jocemar Ilha, Neurological sciences . 2012,第5期

机译：在6-OHDA诱发的帕金森氏病大鼠模型中，运动可改善运动功能障碍并改变纹状体GFAP表达。
2. Combined information from resting-state functional connectivity and passive movements with functional magnetic resonance imaging diferentiate fast late-onset motor recovery from progresive recovery in hemiplegic stroke patients: A pilot study [J] . JungT.-D., KimJ.-Y., SeoJ.-H., Journal of rehabilitation medicine : . 2013,第6期

机译：偏瘫性卒中患者的静止状态功能连通性和被动运动信息与功能磁共振成像相结合，可将快速迟发性运动恢复从渐进性恢复中区分出来
3. Evidence for bilateral control of skilled movements: ipsilateral skilled forelimb reaching deficits and functional recovery in rats follow motor cortex and lateral frontal cortex lesions. [J] . Gonzalez CL, Gharbawie OA, Williams PT, The European Journal of Neuroscience . 2004,第12期

机译：双边控制熟练运动的证据：大鼠同侧熟练前肢达到运动神经皮层和额叶外侧皮损并达到功能恢复。
4. Determining the effects of electrical stimulation on functional recovery of denervated rat gastrocnemius muscle using motor unit number estimation [C] . Willand Michael P., Holmes Michael, Bain James R., 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2011

机译：使用运动单位数估计确定电刺激对失神经大鼠腓肠肌功能恢复的影响
5. 810 nm light treatment of acute spinal cord injury alters the immune response and improves axonal regeneration and functional recovery. [D] . Byrnes, Kimberly R. 2003

机译：810 nm光治疗急性脊髓损伤可改变免疫反应，并改善轴突再生和功能恢复。
6. Probiotic Supplementation Facilitates Recovery of 6-OHDA-Induced Motor Deficit via Improving Mitochondrial Function and Energy Metabolism [O] . Bira Arumndari Nurrahma, Shu-Ping Tsao, Chieh-Hsi Wu, 2021

机译：益生菌补充促进通过改善线粒体功能和能量代谢来促进6-OHDA诱导的电动机缺损
7. A novel diketopiperazine improves functional recovery given after the onset of 6-OHDA-induced motor deficit in rats [O] . Krishnamurthi, RVM, Mathai, S, Kim, AH, 2009

机译：新型二酮哌嗪改善了6-OHDA诱导的大鼠运动功能障碍发作后的功能恢复
8. Improving Motor Reliability in Nuclear Power Plants. Volume 2. Functional Indicator Tests on a Small Electric Motor Subjected to Accelerated Aging, [R] . Subudhi, M., Taylor, J. H., Lofaro, R., 1987

机译：提高核电厂电机可靠性。第2卷。小型电动机在加速老化时的功能指标测试，

A novel diketopiperazine improves functional recovery given after the onset of 6-OHDA-induced motor deficit in rats

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